Rational design of a highly selective UGT1A1 probe and its application in drug discovery
Xin-Fang Zhai, Yi Yang, Rong Yu, Yi Kuang, Sharpkate Shaker, Huifei Su, Guo Ye, Chen-Rui Liu, Xue Qiao, Lei Liang, Min Ye
Topics & Concepts
ChemistrySubstrate (aquarium)Drug discoveryDrugIC50PharmacologySelectivityUridineRational designUridine diphosphateBiochemistryCombinatorial chemistryEnzymeBiologyNanotechnologyIn vitroGeneMaterials scienceCatalysisRNAEcologyPharmacological Effects of Natural CompoundsBiochemical and Molecular ResearchCancer therapeutics and mechanisms