A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917
Jean‐Philippe Nougayrède, Camille V. Chagneau, Jean‐Paul Motta, Nadège Bossuet‐Greif, Marcy Belloy, Frédéric Taïeb, Jean‐Jacques Gratadoux, Muriel Thomas, Philippe Langella, Éric Oswald
Abstract
Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal cancer.
Topics & Concepts
ProbioticEscherichia coliStrain (injury)MicrobiologyBiologyBacterial strainChemistryGeneticsBacteriaGeneAnatomyCarcinogens and Genotoxicity AssessmentBacterial Genetics and BiotechnologyPlant Genetic and Mutation Studies