Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase
Belén Martínez-Gualda, Sirle Saul, Matheus Froeyen, Dominique Schols, Piet Herdewijn, Shirit Einav, Steven De Jonghe
Topics & Concepts
ChemistryMoietyStereochemistryKinaseCarboxamideStructure–activity relationshipHydrogen bondIn vitroBiochemistryMoleculeOrganic chemistryProtein Kinase Regulation and GTPase SignalingBiochemical and Molecular ResearchResearch on Leishmaniasis Studies