MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling
Beibei Fu, Weiwei Xue, Haiwei Zhang, Rui Zhang, Kelly Feldman, Qingting Zhao, Shanfu Zhang, Lei Shi, Krishna Chaitanya Pavani, Weiqi Nian, Xiaoyuan Lin, Haibo Wu
Abstract
Intracellular survival of Mycobacterium tuberculosis results in bacterial proliferation and the spread of infection in lungs, consequently deteriorating the conditions of tuberculosis (TB) patients. This research discovers a new immune escape pathway of M. tuberculosis by modulating host miR-325-3p expression, thus leading to the intracellular survival of M. tuberculosis . These findings make a contribution to the understanding of the immune escape of M. tuberculosis , and they provide a theoretical basis for the development of therapeutic approaches for drug-resistant TB.
Topics & Concepts
Mycobacterium tuberculosisApoptosisImmune systemmicroRNATuberculosisSignal transductionSTAT3BiologyCell biologyMicrobiologyImmunologyChemistryMedicineGeneGeneticsPathologyCancer Mechanisms and TherapyCytokine Signaling Pathways and Interactionsinterferon and immune responses