New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells
Laura Braconi, Elisabetta Teodori, Chiara Riganti, Marcella Coronnello, Alessio Nocentini, Gianluca Bartolucci, Marco Pallecchi, Marialessandra Contino, Dina Manetti, María Novella Romanelli, Claudiu T. Supuran, Silvia Dei
Abstract
were identified as promising chemosensitizer agents for selective inhibition in MDR cancer cells overexpressing both P-gp and hCA XII.
Topics & Concepts
ChemistryP-glycoproteinMultiple drug resistanceEffluxCarbonic anhydraseCancer cellK562 cellsCancerPharmacologyBiochemistryEnzymeIn vitroInternal medicineMedicineAntibioticsEnzyme function and inhibitionDrug Transport and Resistance MechanismsChemical Reaction Mechanisms