Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy
Junjie Liu, Xiu Hua Zhao, Weimin Nie, Yue Yang, Chengcheng Wu, Wei Liu, Kaixiang Zhang, Zhenzhong Zhang, Jinjin Shi
Abstract
Based on these findings, we conclude that the designed SRG could induce sustainable ROS generation, homogeneous intratumoral distribution and intracellular redox homeostasis disruption, presenting an efficient strategy for enhanced ROS-mediated anti-tumor therapy.
Topics & Concepts
IntracellularReactive oxygen speciesChemistryPhotodynamic therapyGlutathioneBiophysicsPhotosensitizerCancer researchSinglet oxygenCell biologyBiochemistryOxygenBiologyPhotochemistryEnzymeOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis