Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib
Neil Parrott, Cordula Stillhart, Marc Lindenberg, Bjoern Wagner, Karey Kowalski, Elena Guerini, Nassim Djebli, Georgina Meneses‐Lorente
Topics & Concepts
Physiologically based pharmacokinetic modellingIn silicoPharmacokineticsChemistryPharmacologyBioavailabilityADMEDrugIn vivoDrug developmentBiochemistryMedicineBiotechnologyBiologyGeneDrug Solubulity and Delivery SystemsProtein purification and stabilityDrug Transport and Resistance Mechanisms