“On‐Water” Synthesis of Sterically Congested γ‐Ketophosphine Oxides Featuring a CF<sub>3</sub>‐ and P(O)‐Tetrasubstituted Carbon Center
Man‐Hang Feng, Wenjun Ji, Bo‐Jie Huo, Hao Xu, Mengtao Ma, Zhi‐Liang Shen, Xue‐Qiang Chu
Abstract
Abstract The distinctive hydrophobic hydration effect in the aqueous solution contributes to the success of the phospha‐Michael reaction between β‐CF 3 ‐β,β‐disubstituted enones and diarylphosphine oxides, providing an access to biologically relevant γ‐ketophosphine oxides bearing a sterically highly congested CF 3 ‐ and P(O)‐tetrasubstituted carbon center. More importantly, the resulting products could be further transformed into densely functionalized γ‐ketophosphine oxides containing a CF 3 ‐ and P(O)‐tetrasubstituted carbon center.
Topics & Concepts
Steric effectsChemistryAqueous solutionCenter (category theory)Carbon fibersStereochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCrystallographyMaterials scienceComposite materialComposite numberFluorine in Organic ChemistryChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis