Apolipoprotein E, low-density lipoprotein receptor, and immune cells control blood-brain barrier penetration by AAV-PHP.eB in mice
Baoshu Xie, Xin Wang, Yaohua Pan, Gan Jiang, Junfeng Feng, Yong Lin
Abstract
Our findings demonstrate that the ApoE-LDLR pathway underlies the CNS tropism of AAV-PHP.eB and that the immune system contributes to the strain specificity of AAV-PHP.eB.
Topics & Concepts
Penetration (warfare)Immune systemBlood–brain barrierApolipoprotein EReceptorLipoproteinLDL receptorApolipoprotein BImmunologyChemistryMedicineCholesterolPathologyCentral nervous systemEndocrinologyBiochemistryDiseaseEngineeringOperations researchBarrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsExtracellular vesicles in disease