Recent Advances in Electrochemical Benzylic C(sp<sup>3</sup>)−H Functionalization
Anni Li, Zhengjun He, Qiang Huang, Hongji Li
Abstract
Direct benzylic C(sp 3 )H functionalization has emerged as a topic in organic synthesis due to its critical role in constructing complex and valuable molecules. Among the various methodologies employed, electroorganic synthesis has garnered considerable attention in diversifying benzylic C(sp 3 )H functionalization. In recent years, substantial progress has been made in electrochemical benzylic C(sp 3 )H functionalization. However, a comprehensive review summarizing recent advancements in this area is still lacking. This review provides an overview of the latest developments (2021–2025) in electrochemical benzylic C(sp 3 )H functionalization, with a particular emphasis on mechanistic insights and practical applications in the synthesis of biologically active molecules. Additionally, current challenges and future perspectives in this field are discussed.