Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia
Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Takashige Kuwabara, Keishi Miyata, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike
Abstract
mice fed a high-cholesterol diet, which represent a model of severe familial hypercholesterolemia (FH) caused by ApoE loss of function. Taken together, ANGPTL3 vaccination could be an effective therapeutic strategy against dyslipidemia and associated diseases.
Topics & Concepts
DyslipidemiaMedicineInternal medicineEndocrinologyVaccinationFamilial hypercholesterolemiaLipoproteinCholesterolObesityImmunologyLipid metabolism and disordersAtherosclerosis and Cardiovascular DiseasesCancer, Lipids, and Metabolism