Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits
Yaxi Li, Zeshun Li, Dehong Hu, Shuxian Wang, Menglei Zha, Song‐Bo Lu, Zonghai Sheng, Kai Li
Abstract
The functional NIR-II emissive nanoprobe loaded with AIEgen (cRGD-TTB NPs) achieved a high quantum yield (10.32%) and a high signal-to-background (S/B) ratio of 7.7 when employed for the visualization of large tumors (∼600 mm3) in rabbit models for the first time. This work will aid in the investigation of tumor targeting effect of therapeutic agents in large animal models.
Topics & Concepts
Yield (engineering)Quantum yieldChemistryNanotechnologyBiophysicsMaterials scienceFluorescencePhysicsBiologyOpticsMetallurgyNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques