Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)
Shima Gholizadeh, Xi Chen, Ann Yung, Amirreza Naderi, Mahsa Ghovvati, Yangcheng Liu, Ashkan Farzad, Azadeh Mostafavi, Reza Dana, Nasim Annabi
Abstract
results confirmed adhesion and retention of the optimized hydrogel subconjunctivally and on the sclera for up to 4 days. The developed formulation has potential to be used as an ocular sealant for quick repair of laceration type ocular injuries.
Topics & Concepts
Self-healing hydrogelsAdhesiveScleraSwellingAdhesionMaterials sciencePolymerGelatinBiomedical engineeringHyaluronic acidComposite materialChemistryPolymer chemistrySurgeryLayer (electronics)BiochemistryBiologyMedicineGeneticsCorneal Surgery and TreatmentsSurgical Sutures and AdhesivesFacial Trauma and Fracture Management