Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands
Miyako Naganuma, Nobumichi Ohoka, Genichiro Tsuji, Haruna Tsujimura, Kenji Matsuno, Takao Inoué, Mikihiko Naito, Yosuke Demizu
Abstract
was found to selectively degrade ERα via the UPS. These findings will be applicable to the development of other oligonucleotide-type degraders that target different TFs.
Topics & Concepts
DecoySmall moleculeFusion proteinOligonucleotideEstrogen receptorTranscription factorUbiquitinCell biologyChemistryTarget proteinComputational biologyBiologyReceptorBiochemistryDNAGeneticsRecombinant DNAGeneCancerBreast cancerProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysRNA Interference and Gene Delivery