Cross-species comparison of pregnancy-induced GDF15
Anders B. Klein, Pablo Ranea‐Robles, Trine S. Nicolaisen, Cláudia Gil, Kornelia Johann, Júlia Prats Quesada, Nina Pistolevij, Kathrine Vauvert Römmelmayer Hviid, Line Olsen, Simone Margaard Offersen, Jørn Wulff Helge, Henriette Svarre Nielsen, Jaco Bakker, Maximilian Kleinert, Christoffer Clemmensen
Abstract
In the present study pregnancy-induced changes in circulating growth differentiation factor 15 (GDF15) in rodents, rhesus macaques, and humans are mapped. In sum, it is demonstrated that humans and macaques exhibit a tremendous increase in placental and circulating GDF15 during pregnancy. In contrast, GDF15 is negligibly increased in pregnant mice and rats, questioning a physiological role for GDF15 in pregnancy in rodents.
Topics & Concepts
GDF15PregnancyMedicineBiologyInternal medicineGeneticsGDF15 and Related BiomarkersNutrition and Health in AgingMacrophage Migration Inhibitory Factor