Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
A-Reum Kim, Seong Jin Choi, Junsik Park, Minsuk Kwon, Tamrin Chowdhury, Hyeon Jong Yu, Sojin Kim, Ho Kang, Kyung-Min Kim, Su-Hyung Park, Chul-Kee Park, Eui-Cheol Shin
Abstract
T cells in the core regions was significantly associated with decreased progression-free survival of patients with HGG. The hypoxic condition in the core region of HGG directly induces an immunosuppressive TIME, which is associated with patient survival.
Topics & Concepts
Immune systemPeripheralFlow cytometryTumor microenvironmentCancer researchImmunologyGliomaBiologyTranscriptomeMedicineImmunotherapyImmunophenotypingCellT cellMass cytometryImmunosuppressionCell cultureHypoxia (environmental)Cytotoxic T cellGlioma Diagnosis and TreatmentImmune cells in cancerCancer, Hypoxia, and Metabolism