IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent
Clare S. Hardman, Yi‐Ling Chen, Maryam Salimi, Janina Nahler, Daniele Corridoni, Marta Jagielowicz, C. L. Fonseka, David Johnson, Emmanouela Repapi, David J. Cousins, Jillian L. Barlow, Andrew N. J. McKenzie, Alison Simmons, Graham S. Ogg
Abstract
mutations. Here, we have identified a role for ILC2 NOD2 signaling in the differential regulation of ILC2-derived IL-6 and have reported a previously unrecognized pathway of direct ILC2 bacterial sensing.
Topics & Concepts
Innate lymphoid cellNOD2BiologyImmunologyTLR2ChemokineInnate immune systemMicrobiologyInflammationImmune systemIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisImmune Cell Function and Interaction