Cinnamaldehyde Targets the LytTR DNA-Binding Domain of the Response Regulator AgrA to Attenuate Biofilm Formation of Listeria monocytogenes
Xiaobing Jiang, Rui Kang, Tao Yu, Xiaojie Jiang, Hong Chen, Yiping Zhang, Yi Li, Hailei Wang
Abstract
binding. Therefore, the occupation of Asn-178 by cinnamaldehyde suppressed transcription of the Agr system and reduced biofilm formation in L. monocytogenes. Our findings could provide a better understanding of the mechanism by which cinnamaldehyde inhibits L. monocytogenes biofilm formation.
Topics & Concepts
Listeria monocytogenesBiofilmQuorum sensingResponse regulatorAgraMicrobiologyBiologyRegulatorChemistryBacteriaBacterial proteinGeneticsGeneEcologyListeria monocytogenes in Food SafetyBacterial biofilms and quorum sensingBiosensors and Analytical Detection