<i>AQP1</i> Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis
Johann Morelle, Céline Maréchal, Zanzhe Yu, Huguette Debaix, Tanguy Corre, Mark Lambie, Marion Verduijn, Friedo W. Dekker, P.H.L. Bovy, Pieter Evenepoel, Bert Bammens, Rafael Selgas, M. Auxiliadora Bajo, Annemieke M. Coester, Amadou Sow, Nicolas Hautem, Dirk G. Struijk, Raymond T. Krediet, Jean‐Luc Balligand, Éric Goffin, Ralph Crott, Pierre Ripoche, Simon Davies, Olivier Devuyst
Abstract
BACKGROUND: , the gene that encodes the archetypal water channel aquaporin-1, may contribute to that variability. METHODS: variant and investigate mitigation strategies. RESULTS: promoter activity, aquaporin-1 expression, and glucose-driven osmotic water transport. The use of a colloid osmotic agent mitigated the effects of the risk variant. CONCLUSIONS: was associated with decreased ultrafiltration and an increased risk of death or technique failure among patients treated with peritoneal dialysis. (Funded by the Swiss National Science Foundation and others.).