New insights into the role of acidocalcisomes in trypanosomatids
Roberto Docampo, Guozhong Huang
Abstract
Abstract Acidocalcisomes are electron‐dense organelles rich in polyphosphate and inorganic and organic cations that are acidified by proton pumps, and possess several channels, pumps, and transporters. They are present in bacteria and eukaryotes and have been studied in greater detail in trypanosomatids. Biogenesis studies of trypanosomatid acidocalcisomes found that they share properties with lysosome‐related organelles of animal cells. In addition to their described roles in autophagy, cation and phosphorus storage, osmoregulation, pH homeostasis, and pathogenesis, recent studies have defined the role of these organelles in phosphate utilization, calcium ion (Ca 2+ ) signaling, and bioenergetics, and will be the main subject of this review.