cAMP is an allosteric modulator of DNA-binding specificity in the cAMP receptor protein from Mycobacterium tuberculosis
Fernanda Gárate, Stephen P. Dokas, Maria Fe Lanfranco, Clare Canavan, Irina Wang, John J. Correia, Rodrigo A. Maillard
Abstract
, illustrating that structural homology does not imply allosteric homology.
Topics & Concepts
Allosteric regulationcAMP receptor proteinMycobacterium tuberculosisAllosteric modulatorChemistryDNAReceptorTuberculosisBiochemistryMedicinePromoterGeneGene expressionPathologyTuberculosis Research and Epidemiologythermodynamics and calorimetric analysesCancer therapeutics and mechanisms