Asymmetric Biomimetic Transamination of Trifluoromethyl Ketones
Weiqi Cai, Dongchen Cai, Hanyu Liang, Xinyi Ren, Baoguo Zhao
Abstract
In the presence of chiral pyridoxamine 4b as the catalyst and 2,2-diphenylglycine ( 3 ) as the amine source, asymmetric biomimetic transamination of trifluoromethyl ketones produces optically active α-trifluoromethyl amines 6 in 81–98% yields with 88–95% ee’s under mild conditions.
Topics & Concepts
TransaminationTrifluoromethylTrifluoromethylationAmine gas treatingChemistryOptically activeCatalysisEnantioselective synthesisOrganic chemistryCombinatorial chemistryAlkylEnzymeFluorine in Organic ChemistryChemical Synthesis and AnalysisSynthesis and Catalytic Reactions