Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study
Rafael José Vieira, Lucas Leemann, Andrew Briggs, Ana Margarida Pereira, Marine Savouré, Piotr Kuna, Mário Morais‐Almeida, M. Bewick, Luís Filipe Azevedo, Renaud Louis, Ludger Klimek, Farah Bahbah, Bolesław Samoliński, Josep M. Antó, Torsten Zuberbier, João Fonseca, Jean Bousquet, Bernardo Sousa‐Pinto, Wienczyslawa Czarlewski, Anna Bedbrook, Tari Haahtela, Giorgio Walter Canonica, Elı́sio Costa, Maciej Kupczyk, Violeta Kvedarienė, Marek Kulus, Désirée Larenas‐Linnemann, Oliver Pfaar, Nikolaos G. Papadopoulos, N. Pham‐Thi, Frederico S. Regateiro, Nicolás Roche, J. Sastre, Nicola Scichilone, Luís Taborda‐Barata, Arūnas Valiulis, Arzu Yorgancıoğlu, Maria Teresa Ventura, Rute Almeida, Rita Amaral, Ignacio J. Ansotegui, Karl‐Christian Bergmann, Sinthia Bosnic‐Anticevich, Fulvio Braido, Luisa Brussino, Victória Cardona, Lorenzo Cecchi, Claudia Chaves Loureiro, Cemal Cingi, Álvaro A. Cruz, Wytske J. Fokkens, Govert de Vries, Bilun Gemicioğlu, Antonio F.M. Giuliana, Tomohisa Linuma, Juan Carlos Ivancevich, Cristina Jácome, Ігор Петрович Кайдашев, Helga Kraxner, Daniel Laune, Gilles Louis, Olga Lourenço, Mika J. Mäkelä, Μichael Μakris, Ralph Mösges, Marcus Maurer, Joaquim Mullol, Rachel Nadif, Marek Niedoszytko, Robyn E. O’Hehir, Yoshitaka Okamoto, Markus Ollert, Heidi Olze, Vincenzo Patella, Benoît Pétré, Francesca Puggioni, Jan Romantowski, Philip W. Rouadi, Sietze Reitsma, Daniela Rivero‐Yeverino, Mónica Rodríguez-González, Ana Sá‐Sousa, Faradiba Sarquis Serpa, Mohamed H. Shamji, Aziz Sheikh, Charlotte Suppli Ulrik, Mikhail Sofiev, Milan Sova, Annette Sperl, Ana Todo‐Bom, Peter Valentin Tomazic, Sanna Toppila‐Salmi, Ioanna Tsiligianni, Erkka Valovirta, M. van Eerd, Mihaela Zidarn, Hubert Blain, Louis‐Philippe Boulet, Guy Brusselle, Roland Buhl
Abstract
BACKGROUND: Allergic rhinitis (AR) and asthma may affect health-related quality of life. However, national estimates on the quality of life of patients with AR or asthma are lacking. OBJECTIVE: To provide estimates for utility scores and EuroQoL five-dimension (EQ-5D) visual analog scale (VAS) for patients with AR or asthma. METHODS: We conducted a cross-sectional study using direct patient data from the MASK-air app on European MASK-air users with self-reported AR or asthma. We used a multi-attribute instrument (EQ-5D) to measure quality of life (as utility scores and EQ-5D VAS values). Mean scores were calculated per country and disease control level using multilevel regression models with poststratification, accounting for age and sex biases. RESULTS: We assessed data from 7905 MASK-air users reporting a total of up to 82,737 days. For AR, utilities ranged from 0.86 to 0.99 for good control versus 0.72 to 0.85 for poor control; EQ-5D VAS levels ranged from 78.9 to 87.9 for good control versus 55.3 to 64.2 for poor control. For asthma, utilities ranged from 0.84 to 0.97 for good control versus 0.73 to 0.87 for poor control; EQ-5D VAS levels ranged from 68.4 to 81.5 for good control versus 51.4 to 64.2 for poor control. Poor disease control was associated with a mean loss of 0.14 utilities for both AR and asthma. For the same control levels, AR and asthma were associated with similar utilities and EQ-5D VAS levels. However, lower values were observed for asthma plus AR compared with AR alone. CONCLUSIONS: Poor AR or asthma control are associated with reduced quality of life. The estimates obtained from mobile health data may provide valuable insights for health technology assessment studies.