Catalyst- and solvent-free C<sub>sp2</sub>–H functionalization of 4-hydroxycoumarins <i>via</i> C-3 dehydrogenative aza-coupling under ball-milling
Goutam Brahmachari, Indrajit Karmakar, Pintu Karmakar
Abstract
A mechanochemistry-driven green and efficient synthetic protocol for bio-relevant coumarin-hydrazones from a one-pot three-component reaction between 4-hydrocoumarins, primary aromatic amines and <italic>tert</italic>-butyl nitrite under ball-milling has been developed.
Topics & Concepts
Ball millCatalysisSurface modificationChemistryMechanochemistryCoupling reactionSolventCoumarinCombinatorial chemistryOrganic chemistryMaterials sciencePhysical chemistryMetallurgyCatalytic C–H Functionalization MethodsBioactive Compounds and Antitumor AgentsSynthesis and Catalytic Reactions