Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
Anurag Singh, Davide D’Amico, Pénélope A. Andreux, Andréane M. Fouassier, William Blanco-Bose, Malkanthi Evans, Patrick Aebischer, Johan Auwerx, Chris Rinsch
Abstract
]) and physical performance (6 min walk test) but do not notice a significant improvement on peak power output (primary endpoint). Levels of plasma acylcarnitines and C-reactive proteins are significantly lower with Urolithin A, indicating higher mitochondrial efficiency and reduced inflammation. We also examine expression of proteins linked to mitophagy and mitochondrial metabolism in skeletal muscle and find a significant increase with Urolithin A administration. This study highlights the benefit of Urolithin A to improve muscle performance.
Topics & Concepts
Randomized controlled trialMuscle strengthPhysical therapyMedicinePhysical medicine and rehabilitationGerontologyInternal medicinePomegranate: compositions and health benefitsAntioxidant Activity and Oxidative StressParaoxonase enzyme and polymorphisms