Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
Simona Bungău, Cosmin Mihai Vesa, Areha Abid, Tapan Behl, Delia Mirela Ţiţ, Anamaria Lavinia Purza, Bianca Pașca, Laura Maghiar Țodan, Laura Endres
Abstract
) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity-numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies.