Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters
Shreyas Bhat, Daryl A. Guthrie, Ameya Kasture, Ali El‐Kasaby, Jianjing Cao, Alessandro Bonifazi, Therese Ku, JoLynn B. Giancola, Thomas Hummel, Michael Freissmuth, Amy Hauck Newman
Abstract
. Hence, a novel lead pharmacochaperone has been identified that demonstrates medication development potential for patients harboring DAT mutations.
Topics & Concepts
TropaneDopamine transporterMutantDopamineBiologyCell biologyMutationChemistryMutagenesisBiochemistryDopaminergicNeuroscienceGeneReceptor Mechanisms and SignalingSignaling Pathways in DiseaseCellular transport and secretion