Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse
Yasmin Kamal, Dennis Dwan, Hannah J. Hoehn, Rebeca Sanz‐Pamplona, M. Henar Alonso, Vı́ctor Moreno, Chao Cheng, Michael J. Schell, Young‐Chul Kim, Seth Felder, Hedy S. Rennert, Marilena Melas, Charalampos Lazaris, Joseph D. Bonner, Erin M. Siegel, David Shibata, Gad Rennert, Stephen B. Gruber, H. Robert Frost, Christopher I. Amos, Stephanie L. Schmit
Abstract
: 241.0). These data suggest that transcriptome-derived immune profiles are prognostic indicators of CRC relapse and quantification of both innate and adaptive immune cell types may serve as candidate biomarkers for predicting prognosis and guiding frequency and modality of disease surveillance.
Topics & Concepts
Microsatellite instabilityImmune systemColorectal cancerOncologyMedicineProportional hazards modelDiseaseInternal medicineImmunologyBiologyCancerGeneGeneticsMicrosatelliteAlleleCancer Immunotherapy and BiomarkersColorectal Cancer Treatments and StudiesColorectal Cancer Surgical Treatments