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HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer

Yi Xiao, Ying Xu, Han Wang, Fan Yang, Xiao-Hong Ding, Tong Fu, Li Chen, Xi Jin, Ya-Xin Zhao, Ying Wang, Fenfang Chen, Zhi‐Ming Shao, Yi-Zhou Jiang

2025Cell Metabolism18 citationsDOI

Topics & Concepts

GlutamineImmunotherapyCancer researchCancer immunotherapyBreast cancerTranscriptomeCrosstalkDownregulation and upregulationMedicineBiologyCancer cellCancerImmunologyGlutathioneIntracellularGlutaminolysisTumor microenvironmentCellMammary tumorInternal medicineImmune cells in cancerEpigenetics and DNA MethylationCancer Immunotherapy and Biomarkers
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer | Litcius