Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology
Michael O’Hagan, Javier Ramos‐Soriano, Susanta Haldar, Sadiyah Sheikh, Juan Carlos Morales, Adrian J. Mulholland, M. Carmen Galán
Abstract
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.
Topics & Concepts
PyridiniumVisible spectrumDNAG-quadruplexChemistryLigand (biochemistry)BiophysicsCombinatorial chemistryMaterials scienceOptoelectronicsBiochemistryBiologyReceptorMedicinal chemistryPhotochromic and Fluorescence ChemistryDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques