Human urine-derived stem cells protect against renal ischemia/reperfusion injury in a rat model via exosomal <i>miR-146a-5p</i> which targets <i>IRAK1</i>
Xirui Li, Jun Liao, Xiaojun Su, Weiqiang Li, Zirong Bi, Jiali Wang, Qun Su, Huiting Huang, Yongcheng Wei, Yifang Gao, Jun Li, Longshan Liu, Changxi Wang
Abstract
and subsequently inhibit the activation of NF-κB signaling and infiltration of inflammatory cells to protect renal function. As a novel cell source, USCs represent a promising non-invasive approach for the treatment of IRI.
Topics & Concepts
IschemiaRenal ischemiaStem cellAcute kidney injuryReperfusion injuryPharmacologymicroRNAUrineMedicineChemistryCell biologyCardiologyInternal medicineBiologyBiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationAcute Kidney Injury Research