Graphene oxide and oxidized carbon nanodiscs as biomedical scaffolds for the targeted delivery of quercetin to cancer cells
Panagiota Zygouri, Grigorios Tsiodoulos, M Angelidou, Eirini Papanikolaou, Antrea-Maria Athinodorou, Yannis V. Simos, Konstantinos Spyrou, Mohammed Subrati, Αntonios Kouloumpis, Angela S. Kaloudi, Georgios Asimakopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Patra Vezyraki, Vasileios Ragos, Dimitrios Gournis
Abstract
anticancer tests were conducted on both normal (NIH/3T3) and glioblastoma (U87) cells. The results revealed that the bonding of quercetin with GO and oxCNDs enhances its cytotoxic effect on cancer cells. GO-Quercetin and oxCNDs-Quercetin induced G0/G1 cell cycle arrest in U87 cells, whereas oxCNDs caused G2/M arrest, indicating a distinct mode of action. In long-term survival studies, cancer cells exhibited significantly lower viability than normal cells at all corresponding doses of GO-Quercetin and oxCNDs-Quercetin. This work leads us to conclude that the conjugation of quercetin to GO and oxCNDs shows promising potential for targeted anticancer activity. However, further research at the molecular level is necessary to substantiate our preliminary findings.