Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis
Sang Hoon Lee, Raquel Tonello, Sang-Taek Im, Hawon Jeon, Jeongsu Park, Zachary K. Ford, Steve Davidson, Yong Ho Kim, Chul‐Kyu Park, Temugin Berta
Abstract
Our findings demonstrate a novel role for RvD3 in regulating TRPV1/CGRP in mouse and human DRG neurons and identify RvD3 and its neuronal pathways as novel therapeutic targets to treat psoriasis.
Topics & Concepts
TRPV1PsoriasisMedicineCalcitonin gene-related peptideInflammationPharmacologyTransient receptor potential channelImmune systemImmunologyNeurogenic inflammationReceptorSubstance PNeuropeptideInternal medicineOlfactory and Sensory Function StudiesDermatology and Skin DiseasesHerbal Medicine Research Studies