Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
Valéria Lima Carvalho, Maureen T. Long
Abstract
Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.
Topics & Concepts
ArbovirusVirologyBiologyArbovirus InfectionsVector (molecular biology)OutbreakVirusGeneticsGeneRecombinant DNAMosquito-borne diseases and controlViral Infections and VectorsInsect symbiosis and bacterial influences