NIR-activated quercetin-based nanogels embedded with CuS nanoclusters for the treatment of drug-resistant biofilms and accelerated chronic wound healing
Amit Nain, Yu‐Ting Tseng, Akash Gupta, Yu‐Feng Lin, Arumugam Sangili, Yu‐Fen Huang, Chih‐Ching Huang, Huan‐Tsung Chang
Abstract
-associated biofilms in diabetic mice wounds. Furthermore, the nanocomposites were found to suppress proinflammatory cytokines, such as IL-1β, at the wound sites while regulating the expression of anti-inflammatory factors, including IL-10 and TGF-β1, throughout the recovery process. The presence of CuS/Qu-CNGs promoted angiogenesis, epithelialization, and collagen synthesis, thereby accelerating wound healing. Our developed CuS/Qu-CNGs nanocomposites have great potential in addressing the challenges associated with delayed wound healing caused by microbial pathogenesis.
Topics & Concepts
BiofilmProinflammatory cytokineAntimicrobialWound healingStaphylococcus aureusChemistryNanocompositeMaterials scienceMicrobiologyNanoclustersNanotechnologyBacteriaInflammationMedicineImmunologyBiologyOrganic chemistryGeneticsGraphene and Nanomaterials ApplicationsNanoplatforms for cancer theranosticsWound Healing and Treatments