Baclofen-induced neurotoxicity in chronic kidney disease: Is there a safe dose?
PremP Varma, Geet Bajpai
Abstract
<br>Most cases of Baclofen toxicity have been reported in patients with impaired kidney functions, within a few days to weeks after ingestion. We report three cases of Baclofen induced encephalopathy in chronic kidney disease patients; two developed encephalopathy within 6–8 h after ingestion of a single tablet and third on 4<sup>th</sup> day of consuming 2.5 mg twice daily dose. All three cases recovered fully following haemodialysis treatment.<br>
Topics & Concepts
MedicineBaclofenNeurotoxicityEncephalopathyKidney diseaseIngestionToxicityKidneyAnesthesiaHypertensive encephalopathyGastroenterologyInternal medicineToxic encephalopathyDiseasePharmacologyAcute kidney injurySurgeryBotulinum Toxin and Related Neurological DisordersNeurological and metabolic disordersPoisoning and overdose treatments