Multi-target cell therapy using a magnetoelectric microscale biorobot for targeted delivery and selective differentiation of SH-SY5Y cells<i>via</i>magnetically driven cell stamping
Hyunseok Song, Dong‐In Kim, Sarmad Ahmad Abbasi, Nader Latifi Gharamaleki, Eunhee Kim, Chaewon Jin, Samhwan Kim, Junsun Hwang, Jinyoung Kim, Xiangzhong Chen, Bradley J. Nelson, Salvador Pané, Hongsoo Choi
Abstract
magnetoelectric (ME) stimulation. This ensures rapid colonization and enhances efficacy. SMMBs were fabricated using SH-SY5Y cells. Magnetoelectric nanoparticles for ME stimulation responded to an alternating magnetic field that ensured targeted cell differentiation. Multi-target cell therapy facilitated the targeted delivery and selective differentiation of SH-SY5Y cells to multiple regions using a single SMMB with rotating and alternating magnetic fields for delivery and ME stimulation. This promising tool may overcome the limitations of existing cell therapy for neurodegenerative diseases.