27-Hydroxycholesterol-induced EndMT acts <i>via</i> STAT3 signaling to promote breast cancer cell migration by altering the tumor microenvironment
Kai Jiao, Jing Zhen, Maoxuan Wu, Mengying Teng, Keke Yang, Qian Zhou, Chunyan Hu, Ming Zhou, Yuan Li, Zhong Li
Abstract
Cross-talk between 27HC-induced EndMT and EMT was observed in the TME. Moreover, activation of STAT3 signaling was found to be involved in 27HC-induced EndMT.
Topics & Concepts
Western blotChemistrySTAT3Cell migrationGene knockdownEpithelial–mesenchymal transitionUmbilical veinCellCancer researchMetastasisCell biologyMolecular biologySignal transductionCancerBiologyApoptosisBiochemistryIn vitroGeneGeneticsCancer-related molecular mechanisms researchCancer, Lipids, and MetabolismMicroRNA in disease regulation