Precision in cancer diagnostics: ultra-sensitive detection of MCF-7 breast cancer cells by gold nanostructure-enhanced electrochemical biosensing
Mahsa Rahmanipour, Hossein Siampour, Ahmad Moshaii, Masoud Amirabadizadeh, Mohamad Hassan Fouani, Laleh Shariati, Mohammad Rafienia
Abstract
a facile galvanic replacement process. Functionalizing these gold nanostructures with aptamers targeting the MUC1 glycoproteins, a prominent cancer biomarker, enables specific recognition of MCF-7 breast cancer cells. The proposed electrochemical sensing platform offers several advantages, including high selectivity, a wide linear range of detection, a low detection limit of 30 cells per mL, and long-term stability, rendering this sensor highly desirable for definitive breast cancer diagnosis.
Topics & Concepts
MCF-7NanostructureBiosensorBreast cancerNanotechnologyMaterials scienceCancerCancer detectionCancer researchMedicineHuman breastInternal medicineAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionAdvanced Biosensing Techniques and Applications