A vinyl-decorated covalent organic framework for ferroptotic cancer therapy <i>via</i> visible-light-triggered cysteine depletion
Qun Guan, Lele Zhou, Wei Zhou, Yu‐Bin Dong
Abstract
lipid raft- and caveolin-related endocytosis and induces lipid peroxidation and ferroptosis by consuming cysteine, exhibiting powerful therapeutic activity against colon cancer. We believe that this study both enriches the ambient synthesis of nanoscale COFs and highlights the feasibility of intracellular photochemical reactions for tumor therapy.
Topics & Concepts
CysteineGlutathioneCovalent bondCovalent organic frameworkChemistryIntracellularEndocytosisLipid peroxidationClick chemistryBiophysicsBiochemistryCombinatorial chemistryOxidative stressOrganic chemistryEnzymeBiologyCellNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsSulfur Compounds in Biology