Assembly of the Hydroxycinnoline Core via Hydrazide-Assisted Rh(III)-Catalyzed C–H Functionalization and Annulation
Suho Kim, Heon Kyu Park, Neeraj Kumar Mishra, In Su Kim, Ju Young Kang
Abstract
Abstract The structural modification of phthalazinones and indazolones has emerged as a pivotal topic in catalytic C–H functionalization events. Herein we report the hydrazide-assisted rhodium(III)-catalyzed cross-coupling reactions of N-arylphthalazinones and N-arylindazolones with vinylene carbonate. This method provides direct access to tetracyclic hydroxycinnolines. Complete site-selectivity and functional group compatibility were observed.
Topics & Concepts
ChemistrySurface modificationAnnulationHydrazideCatalysisRhodiumSelectivityCombinatorial chemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions