Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors
Yue Xu, Caiquan Liang, Wannian Zhang, Jianqiang Yu, Chengguo Xing, Huanhai Liu, Chunlin Zhuang
Topics & Concepts
NecroptosisRIPK1BenzothiazoleChemistryProgrammed cell deathKinaseCaspase 8PhosphorylationChemical spaceApoptosisCell biologyBiochemistryCaspaseDrug discoveryBiologyCell death mechanisms and regulation