Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease
Satoshi Miyamoto, Guanshi Zhang, David L. Hall, Peter J. Oates, Soumya Maity, Muniswamy Madesh, Xianlin Han, Kumar Sharma
Abstract
mice. These results indicate that, in type 2 diabetes, DKD is associated with reduced renal and cardiac superoxide levels and that MTP-131 protects against DKD and preserves physiological superoxide levels, possibly by regulating cardiolipin remodeling.
Topics & Concepts
SuperoxideEndocrinologyMitochondrionKidneyInternal medicineKidney diseaseMedicineChemistryBiologyBiochemistryEnzymeMitochondrial Function and PathologyAdipose Tissue and MetabolismBirth, Development, and Health