Visible-Light Photocatalytic Tri- and Difluoroalkylation Cyclizations: Access to a Series of Indole[2,1-<i>a</i>]isoquinoline Derivatives in Continuous Flow
Xin Yuan, Xiu Duan, Yu‐Sheng Cui, Qi Sun, Long‐Zhou Qin, Xinpeng Zhang, Jie Liu, Meng‐Yu Wu, Jiang‐Kai Qiu, Kai Guo
Abstract
]isoquinoline derivatives is described. This protocol utilized an inexpensive organic photoredox catalyst and provided good yields. Moreover, the combination of continuous flow and photochemistry, designed to provide researchers with a unique green process, was also shown to be key to allowing the reaction to proceed (product yield of 83% in flow vs 0% in batch).
Topics & Concepts
IsoquinolineChemistryIndole testPhotocatalysisYield (engineering)Combinatorial chemistryCatalysisPhotochemistryVisible spectrumContinuous flowOrganic chemistryBiochemical engineeringOptoelectronicsEngineeringMetallurgyMaterials sciencePhysicsFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods