Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M
Min Shi, Ning Ye, Wei Chen, Hui Wang, Chi‐Ming Cheung, Michaël Parmentier, Fabrice Gallou, Bin Wu
Abstract
The technology of surfactant chemistry is employed for amide bond construction via the reaction of acyl chlorides with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling of the TPGS-750-M solution.
Topics & Concepts
Aqueous solutionChemistryAmidePulmonary surfactantCombinatorial chemistryOrganic chemistryChromatographyBiochemistryChemical Synthesis and AnalysisChemical Synthesis and ReactionsAnalytical Chemistry and Chromatography