Expanding Bromodomain Targeting into Neglected Parasitic Diseases
C. Tallant, Paul Bamborough, Chun‐wa Chung, Francisco‐Javier Gamo, Robert B. Kirkpatrick, Chris Larminie, Julio Martín, Rab K. Prinjha, Inmaculada Rioja, Daniel F. Simola, Raquel Gabarró, Félix Calderón
Abstract
This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launch drug discovery campaigns to identify and develop antiparasite drugs that can offer differentiated mechanisms of action.
Topics & Concepts
BromodomainContext (archaeology)Neglected tropical diseasesDrug discoveryProtozoaAntiparasitic agentBiologyMedicineBioinformaticsDiseasePharmacologyPathologyGeneticsGeneAcetylationPaleontologyProtein Degradation and InhibitorsPlant Virus Research StudiesHIV Research and Treatment