Focused ultrasound ablation of melanoma with boiling histotripsy yields abscopal tumor control and antigen-dependent dendritic cell activation
E. Andrew Thim, Lydia E. Kitelinger, Fátima Rivera‐Escalera, Alexander S. Mathew, Michael R. Elliott, Timothy N. J. Bullock, Richard J. Price
Abstract
: When applied with a sparse scan protocol, BH monotherapy elicits abscopal melanoma control and shapes dendritic cell function through several previously unappreciated mechanisms. These results offer new insight into how to best combine BH with immunotherapies for the treatment of metastatic melanoma.
Topics & Concepts
AntigenImmunotherapyDendritic cellTumor antigenAntigen-presenting cellCancer researchMelanomaAbscopal effectAntigen presentationImmune systemFlow cytometryT cellChemistryImmunologyMedicineImmunotherapy and Immune ResponsesMicrofluidic and Bio-sensing Technologies3D Printing in Biomedical Research