Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis
Tao Cheng, Shuai Ding, Shanshan Liu, Yan Li, Lingyun Sun
Abstract
mice, which is attributable for promoting splenic CD4+ T cell senescence through Sirt1/p53 pathway.
Topics & Concepts
SenescenceMesenchymal stem cellSystemic lupus erythematosusTransplantationCancer researchMedicineImmunologyIn vivoStem cellBiologyInternal medicineCell biologyPathologyDiseaseBiotechnologyMesenchymal stem cell researchCytomegalovirus and herpesvirus researchMicroRNA in disease regulation