Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease
Ling Zhang, Qian Liu, Haoran Hu, Lu Zhao, Keyang Zhu
Abstract
Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria transfer can promote wound healing and can potentially be applied to the repair of damaged tissue, but the specific mechanisms and regulatory factors involved remain unclear. In this review, we discuss the mechanistic basis of mitochondria transfer and factors that restore mitochondrial function in injured somatic cells.
Topics & Concepts
Mesenchymal stem cellMitochondrionWound healingCell biologyStem cellTissue repairCellSomatic cellBiologyImmunologyBiochemistryGeneMesenchymal stem cell researchAutophagy in Disease and TherapyExtracellular vesicles in disease