Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis
Tim I.M. Korevaar, Arash Derakhshan, Peter Taylor, Marcel E. Meima, Liangmiao Chen, Sofie Bliddal, David Carty, Margreet Meems, Bijay Vaidya, Beverley M. Shields, Farkhanda Ghafoor, Polina Popova, Lorena Mosso, Emily Oken, Eila Suvanto, Aya Hisada, Jun Yoshinaga, Suzanne J. Brown, J.M. Roca Bassols, Juha Auvinen, Wichor M. Bramer, Abel López‐Bermejo, Colin Dayan, Laura Boucai, Marina Vafeiadi, Elena Grineva, Alexandra S. Tkachuck, Victor J.M. Pop, Tanja G. M. Vrijkotte, Mònica Guxens, Leda Chatzi, Jordi Sunyer, Ana Jiménez-Zabala, Isolina Riaño, Mario Murcia, Xuemian Lu, Shafqat Mukhtar, Christian Delles, Ulla Feldt‐Rasmussen, Scott M. Nelson, Erik K. Alexander, Layal Chaker, Tuija Männistö, John P. Walsh, Elizabeth N. Pearce, Eric A.P. Steegers, Robin P. Peeters
Abstract
(Abstracted from JAMA 2019;322(7):632–641) Preterm birth complicates 5% to 15% of births worldwide, and although it is the most important direct cause of morbidity and mortality in children younger than 5 years, no known risk factors can be identified in the majority of cases. However, overt hypothyroidism and hyperthyroidism during pregnancy are well-known risk factors for preterm birth, and as such, the purpose of this study was to assess whether thyroid function test abnormalities and thyroid peroxidase (TPO) antibody positivity were associated with preterm birth.